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Obtaining injections outside regulated NHS settings may involve inappropriate dosing, lack of monitoring, non-sterile technique, and unnecessary financial cost without clinical benefit

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ATTAIN-2 (NCT05872620) This trial evaluated orforglipron in adults with obesity or overweight who also had type 2 diabetes, a critically important subpopulation given the high co-prevalence of these conditions

This restores tubuloglomerular feedback , leading to constriction of the afferent arteriole and reduction of intraglomerular pressure