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Side effects including nausea, vomiting, dehydration, and pancreatitis are dose-dependent and occur more frequently at higher exposures

Shojaan, S., Andarzbakhsh, K., Targhi, H.J., Namvar, S., Shiehmorteza, M., Rad, H.G., Rezazadeh, H.: Evaluating the efficacy of bromelain and curcumin in treating acne scars: a randomized clinical trial

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Etiology / Risk Factors Areca nut (betel nut) chewing (most important) Betel quid with tobacco Chillies (capsaicin) Nutritional deficiencies (iron, vitamins A & B complex) Genetic and immunologic factors 2