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Among them, dimethyl biguanide (known as metformin) was selected for clinical development with the suggestive name of Glucophage, which means glucose eater. The other biguanides, phenformin and buformin, were more potent than metformin, however in the late 1970s they were removed in most countries because of their association with lactic acidosis (Seyfried et al., 2014

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Evolution of angiotensin peptides and peptidomimetics as angiotensin II receptor type 2 (AT2) receptor agonists