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doi: 10.1158/1535-7163.MCT-08-0840

Although the pathophysiology of hypertension is extremely complex and multifactorial, and the role of factors such as endothelin, 2 cyclooxygenase-dependent vasoconstrictors 3 and endothelium-derived hyperpolarizing factor 4 needs to be acknowledged, numerous experimental animal studies suggest that this condition is associated with an increased formation of reactive oxygen species (ROS) from all layers of the vascular wall

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Elbatreek MH, Pachado MP, Cuadrado A, Jandeleit-Dahm K, Schmidt H