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It is normally involved in the metabolism of every cell of the body, especially affecting DNA synthesis and regulation, but also fatty acids synthesis and energy production

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Source data Rights and permissions About this article Cite this article Yuan, S., Yin, X., Meng, X

Binding, agonism, internalization, and -arrestin recruitment Studies published by 49 and 48 have documented the physiologic relevance of internalization and -arrestin recruitment in response to specific interactions with both the GLP-1R and Y2-R 49 demonstrated that the extent of internalization and receptor trafficking mediated by Ex-4 (the scaffold upon which GEP44 is built) has a direct impact on the ISR and that efforts to retain GLP-1R on the cell surface result in enhanced and sustained insulin release