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Antioxidants and metal chelating agents also can be used to prevent oxidation in protein formulations

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Methylcobalamin B12 is also indicated in those with pernicious anemia, diabetes, neuropathy, heart disease, circadian rhythm sleep disorders, memory loss, depression, fatigue, AIDS, inflammatory bowel disease (IBD), Lyme disease, osteoporosis, tendonitis, psychiatric disorders, Alzheimers disease, liver and kidney disease, and asthma

In addition, 25% of the vitamin D3 plus simvastatin recipients had a 50% or greater reduction in migraine days, while only 3% of placebo recipients achieved this level of response (Buettner 2015)