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combination glp-1 and sglt2

combination glp-1 and sglt2 Inhibitors Receptor Agonists in Diabetic Kidney Disease: Evolving Evidence and Clinical Application Frontiers | Mechanisms of action

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combination glp-1 and sglt2 Inhibitors Receptor Agonists in Diabetic Kidney Disease: Evolving Evidence and Clinical Application Frontiers | Mechanisms of action

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combination glp-1 and sglt2 Inhibitors Receptor Agonists in Diabetic Kidney Disease: Evolving Evidence and Clinical Application Frontiers | Mechanisms of action

According to this, the first hit is induced by the accumulation of lipids in hepatocytes from high-caloric intake, obesity, insulin resistance, which makes the liver vulnerable to other damaging factors that are referred to as the second hits, such as oxidative stress, genetic polymorphisms (65)

combination glp-1 and sglt2 Inhibitors Receptor Agonists in Diabetic Kidney Disease: Evolving Evidence and Clinical Application Frontiers | Mechanisms of action

However, the efficacy of GLP-1R agonists in biopsy-proven NASH patients varies, suggesting that the expression levels of GLP-1R may be different in these patients

combination glp-1 and sglt2 Inhibitors Receptor Agonists in Diabetic Kidney Disease: Evolving Evidence and Clinical Application Frontiers | Mechanisms of action
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