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This effect is likely mediated by enhanced energy production in surviving cardiomyocytes

However, we focused this review on sulforaphane due to its overwhelming use in neuronal disease models and clinical trials

These materials demonstrate high pH sensitivity, where acidic conditions trigger a surge in fluoride release, particularly pronounced in systems containing CaF 2 or fluorohydroxyapatite under cariogenic pH (4.5-5.5) generated by bacterial metabolism (Morawska-Wilk et al., 2025)

- People with significant liver disease (the 9-month monkey toxicology study showed dose-dependent periportal vacuolation in hepatocytes that the FDA flagged as a possible safety signal)