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On May 1, 2026, Health Canada authorized a second generic semaglutide injection, filed by Canadian-based Apotex, and said it was reviewing seven other submissions from different companies [Source: canada.ca/en/health-canada/news/2026/05/canada-approves-second-generic-semaglutide-the-first-g7-country-to-do-so.html]

Based on the anticipated Phase 3 timelines, regulatory submissions are unlikely before the mid-to-late 2020s, though this is contingent on trial completion and data review processes

In this review, we will systematically summarize the recent progress in amino acid metabolism in the context of cancer and the tumor microenvironment, describe their interconnection or indispensable role in cancer growth, epigenetic modification, cancer immunity, and ferroptosis, and discuss the potential therapeutic applications for targeting amino acid metabolism

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