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[DOI] [PMC free article] [PubMed] [Google Scholar] 114.Zhang L., Hanigan M.H

In SURMOUNT-1 , a 72-week Phase 3 double-blind trial in 2,539 adults with obesity (or overweight with a complication) but without diabetes, once-weekly tirzepatide produced mean weight changes of 15.0% (5 mg), 19.5% (10 mg), and 20.9% (15 mg) versus 3.1% with placebo, with 5057% of participants on the higher doses losing at least 20% of body weight

Proper hydration supports cellular function, helps flush metabolic byproducts, and can reduce potential injection site reactions

The peptide should dissolve into a clear, colourless solution within a minute or two