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Important safety considerations include the recommendation to discontinue semaglutide at least 2 months before a planned pregnancy, as specified in FDA labeling

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Individuals with significant gastrointestinal issues or certain heart conditions should also discuss risks with a healthcare provider

Data acquisition and image processing The purified tirzepatideGIPRG s Nb35 complex at a concentration of 18-20 mg/mL was mixed with 100 M tirzepatide at 4 C and applied to glow-discharged holey carbon grids (Quantifoil R1.2/1.3, Au 300 mesh) that were subsequently vitrified by plunging into liquid ethane using a Vitrobot Mark IV (ThermoFisher Scientific)