However, only five drugs have been approved for the treatment of AD, but these drugs do not significantly control symptoms or change the course of the disease [24]
Patch-clamp analysis pointed to an impairment of K Ca 1.1 upon Gb3 accumulation in fibroblasts and an activation of Notch signaling, finally resulting in an upregulation of pro-inflammatory cytokines, which could be a mechanism contributing to the cutaneous pain seen in patients
When to seek medical advice: Persistent or severe nausea and vomiting that prevents adequate fluid or food intake Signs of dehydration (dark urine, dizziness, extreme thirst) Severe abdominal pain, which could indicate pancreatitis (a rare but serious side effect) Symptoms of hypoglycaemia (shakiness, sweating, confusion, rapid heartbeat) Sudden visual changes (retinopathy risk, particularly with rapid HbA1c improvement) Symptoms of gallbladder disease (severe upper abdominal pain, jaundice) Signs of severe allergic reaction (swelling of face/lips/tongue, breathing difficulty) call 999/112 Your healthcare team will typically review your HbA1c about 3 months after starting treatment and after each dose change
If you experience severe abdominal pain that doesnt go away and radiates to your back, seek medical evaluation as soon as possible
