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During the randomized treatment period, patients received a standard lifestyle instruction every 12 weeks on reduced-calorie diet (approximately 500 kcal/day deficit) and increased physical activity (recommended minimum of 150 min/week) that began with the first dose of ZEPBOUND or placebo and continued throughout the 72-week treatment period
doi: 10.1016/j.amjms.2016.01.011 Lau LH, Lew J, Borschmann K, Thijs V, Ekinci EI
Our selection includes thoroughly reviewed options with consistent dosing and safety data from extensive clinical trials
It does several things simultaneously: it slows gastric emptying (meaning food moves more slowly from your stomach into your intestine, prolonging the sensation of fullness), it stimulates insulin release, it suppresses glucagon, and critically, it sends satiety signals directly to the hypothalamus and brainstem via receptors in both organs
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