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Animal studies showed retatrutide producing lower expression levels of inflammatory and fibrotic mediators compared to tirzepatide, suggesting the triple mechanism may offer benefits beyond additional weight loss

Hepatic laboratory testing is recommended for all patients and the drug may need to be discontinued if alanine transaminase levels hit 10 times the high end of the normal range or liver inflammation develops

Role of oxidative stress and nitric oxide in atherothrombosis

The combination of 2.4 mg/week cagrilintide with semaglutide led to the most significant weight loss (-17.1% from baseline), and both the 2.4 and 4.5 mg/week doses showed an identical placebo-adjusted weight reduction of -7.4% [10]