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ABSTRACT INTRODUCTION BASIC MECHANISMS OF SLEEP AND SLEEP DYSREGULATION MELATONIN GABA CORTISOL BLOOD GLUCOSE DYSREGULATION THE MENSTRUAL CYCLE: AN OVERVIEW SLEEP AND THE MENSTRUAL CYCLE SLEEP AND GLUCOSE METABOLISM THE RELATIONSHIP OF PROGESTERONE, MELATONIN, GABA, AND CBT TO SLEEP DISTURBANCE: A THEORETICAL MODEL CLINICAL IMPLICATIONS Minimize need for pharmaceutical sleep-aids, which often have harmful side effects Reduce the risk of certain chronic diseases (e.g

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9.1 Criteria suggesting failed pharmacology rather than failed biology Several characteristics consistently indicate that a peptide system may have been abandoned prematurely due to pharmacologic or methodological limitations rather than biological inadequacy

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