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1 Introduction Cardiovascular disease (CVD) is the leading cause of mortality worldwide, accounting for nearly one-third of global deaths each year (Roth et al., 2020)

Each vial contains 10mg of Retatrutide in a lyophilized (freeze-dried) form, designed specifically for laboratory research and analytical purposes

Ozempic is a GLP-1 receptor agonist licensed exclusively for subcutaneous injection into fatty tissue beneath the skin

The triple-agonist hypothesis predicts that GIP receptor activation, by enhancing insulin secretion and improving glycemic control, will offset the hyperglycemic effects of glucagon receptor activation while preserving its energy-expenditure benefits