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however, original research data directly comparing comorbid patients with patients having single conditions are currently lacking

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In another rat model of DN, ALA administration for 5 weeks attenuated proteinuria by downregulating renal cortical expression of fibrotic markers, transforming growth factor-beta1 (TGF-1) and fibronectin, via inhibition of p38 MAPK signaling pathway (Lee et al., 2009), and inhibited proliferation of high glucose-exposed human mesangial cells via the same mechanism (Zhang et al., 2021) (Fig

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