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Topline results released last month from the Phase III ATTAIN-MAINTAIN trial (NCT06584916) found that over 52 weeks, orforglipron achieved the primary endpoint in producing superior percent maintenance of weight loss vs

For weight management, a patient typically needs a BMI of 30 kg/m or greater, or a BMI of 27 kg/m or greater with at least one weight-related comorbidity such as hypertension or type 2 diabetes , based on FDA-aligned benchmarks described here

49, 51 In addition, a woman who is diagnosed with IC/BPS will incur a higher mean cost than a male patient diagnosed with the same condition

However, the medication's labeling includes specific pregnancy guidance, and significant weight changes can influence reproductive function through indirect pathways