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These data are primarily gathered in preclinical or early-stage human studies focused on pharmacokinetics and delivery mechanisms

For example for VLCAD deficiency, the ratio of tetradecenoylcarnitine (C14:1) over acetylcarnitine (C2) resulted in less false-negative results when compared to C14:1 as the only marker [46, 57]

541 The BBB controls the entry of circulating substances and cells into the brain, maintaining the stability of normal brain function and serving as the primary barrier for iron entry