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Risk- benefit of treating LM In Strategies for reducing final surgical defect sizes in the treatment of lentigo maligna, Sampson and Bowen (Derm Surg April 2020 46 4 537-43) speculate that the risk of death corresponds to a 99.91% survival rate at 10 years for locally recurrent LM or approximately 1 death in 10,000 (Staged excision of LM then recurrence 5.9% x these recurring as stage IA MM 22.6% x 7% risk of death at 10 years from stage IA = 0.09%)

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341 used exosomes derived from natural killer (NK) cells as a carrier of siRNA targeting BCL-2 to treat patients with estrogen receptor-positive (ER + ) breast cancer, resulting in enhanced apoptosis of breast cancer cells