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The DEGs with known function that are positively regulated by Cyss deprivation in an NRF2-dependent manner are stress response genes involved in endoplasmic reticulum (ER) stress response and autophagy ( DDIT4 , CREB3L4 , DDIT3 , XAF1 , NUPR1, and GADD45B ) [32,33,34,35,36], mitophagy ( MORN4 ) [37] or mitochondrial biogenesis ( TFB1M ) [38]

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Several explanations have been proposed to clarify these differences such as different protocols (antibodies, dilutions, antigen retrieval, and cutoff) and the variable frequency of NF1-associated vs sporadic and radiation-associated malignant peripheral nerve sheath tumors between these cohorts

doi: 10.1016/j.freeradbiomed.2022.01.002 301 ChenZZhengNWangFZhouQChenZXieLet al