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Additionally, lipoic acid increased mitochondrial biogenesis through triggering AMP-activated protein kinase (AMPK)-induced transcription factor PGC-1 activation in skeletal muscle of aged mice (48)

doi: 10.5296/jas.v8i3.16793 41 DongX.ZhouZ.WangL.SaremiB.HelmbrechtA.WangZ.et al

Additionally, the epididymal white adipose tissue, one of the major triglyceride storage tissues, was found not to be impacted by the loss of Gclc and reduced triglycerides in the Gclc L-KO mice (Fig