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Double-checking the temperature in the fridge (2C to 8C) and keeping the pens away from cooling elements can help prevent freezing

doi: 10.1159/000351376

Although doses of DPP-4 inhibitors that reduce enzyme activity in the intestinal lumen without prominent systemic effects (gut-selective) improve glucose tolerance and increase both GLP-1 and GIP, they are not as potent as doses that decrease plasma DPP-4 activity as well [19, 20]