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This phenomenon, known as metabolic endotoxemia, has been linked to: Chronic inflammation Insulin resistance Obesity Metabolic syndrome In animal studies, even modest increases in circulating endotoxins have been shown to trigger inflammatory responses that interfere with metabolic regulation

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[1] In a study published by the New England Journal of Medicine, study participants treated with semaglutide were found to have lost an average of 14.9% of their body weight at week 68, as compared to 2.4% of participants treated with a placebo