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reported that PEGylated long-circulating liposomes increased the AUC 0 of isoquercitrin (IQ) from 11.25 0.75 g hmL 1 to 103.13 4.16 g hmL 1 , prolonged the half-life from approximately 2.6 h15.3 h, and maintained detectable blood drug concentrations at 48 h, whereas free drugs were undetectable after 12 h, demonstrating significantly prolonged circulation time and exposure

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