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For example, HIF-1, which is increasingly stabilized in inflammatory lesions, protects against inflammation and IBD by triggering the transcription of several genes that allow the intestinal epithelial cells to operate as an efficient barrier ( Figure 1 ) ( Nrf2 overexpression was reported to improve UC ( Figure 1 2 Concepts of cellular and ROS damage The intestinal mucosa in people with IBD (e.g., CD) is typically infiltrated with numerous inflammatory cells, including neutrophils, macrophages, and lymphocytes ( The active inflammatory process is coupled with the generation and release of ROS from infiltrating immune cells

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So, gradually moving into heat makes sense, and finding that threshold which is safe and comfortable for you, or if it's uncomfortable, at least resides within that realm of safety