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This aspect could reflect an altered action of ghrelin on its specific receptors implicated in feedback mechanisms.83 Regarding the role of CCK in inhibiting food intake, CCK-A receptor knockout rats are hyperphagic and obese.84 In animals, as expected, repeated preprandial administration of CCK reduces food intake but it also increases meal frequency, with no resulting effect on body weight.85 Circulating levels of PYY are not elevated in obese individuals

Previously, a meta-analysis reported that 13 out of 14 studies showed increases in at least one measure of inflammation either in a subgroup of patients or throughout the whole post-COVID period [66]