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The authors of the study suspect that it is not just weight loss that improved participants heart health

This study found that GLP-1s may be linked to a reduced risk of arrhythmias, especially among people with Type 2 diabetes who have myocardial infarctions (heart attacks)

When oral peptide programs advanced into clinical development, they encountered one or more insurmountable obstacles: extreme inter- and intra-subject variability, inability to meet bioequivalence criteria, unacceptable local gastrointestinal class effects at effective doses, or prohibitive cost of goods due to dose escalation ( An important caveat regarding the evidence base deserves acknowledgment: the oral peptide literature is subject to substantial publication bias

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