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Nrf2 activators like sulforaphane have a potential role with dual antiviral and anti-inflammatory properties in the management of viral pneumonia, a serious complication in COVID-19 disease (Bousquet et al., 2020

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The temporal action profile thus alternates between resting periods (during which GLP-1 receptors are not activated) and intervals (lasting several hours) during which patients are exposed to effective circulating drug concentrations

Upstream kinases that determine clock periodicity also influence liver fat accumulation: disruption of casein kinase 1/ key regulators of PER protein stabilityabolishes rhythmic lipid metabolic oscillations and increases vulnerability to high-fat-dietinduced steatosis (45, 46)