semaglutide and ghrelin Acyl-ghrelin is produced by stomach P/D1 cells. It enters the Photo by MEDICINE EXPERT (@medpert)

A research letter based on this was published in the journal JAMA Internal Medicine in August 2022

If youre feeling cold on semaglutide, its likely due to the weight loss youve achieved in concert with the medicinebut the drug itself plays a role, too

The data supports tirzepatide as a highly effective tool, perhaps one of the most effective pharmacological options currently available, but calling it a miracle oversimplifies the complexity of weight management and sets unrealistic expectations that could lead to frustration and treatment abandonment

Results Compared with the earlier period new users, later period new users in both cohorts were older, had more severe CKD, used less intensive type 2 diabetes medication, and had better metabolic control