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In addition to evaluating RPM supplementation during the last trimester of gestation (last 90 days), Alfaro et al

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Evidence for the traditional inflammatory theory is as follows: tumor necrosis factor alpha (TNF-), IL-6, IL-1, IL-17, and other inflammatory cytokines involved in RA could exert pro-osteoclastogenic effects and suppress bone formation in the appropriate environment via adequate signals, such as the receptor activator of nuclear factor kappa-B ligand (RANKL) and macrophage colony-stimulating factor (M-CSF)

Free Radic Biol Med (2005) 39(5):5849