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Patients should: Weigh themselves at the same time daily (particularly important for those with or at risk for heart failure), reporting sudden gains of 2-3 pounds overnight or 5 pounds within a week Note any new or worsening swelling in the legs, ankles, or abdomen Track blood pressure regularly, as hypertension often accompanies fluid retention Maintain a symptom diary including shortness of breath or reduced exercise tolerance Lifestyle modifications support healthy fluid balance

An aminoisobutyric acid (Aib) substitution at position 8 resists degradation by the DPP-4 enzyme

Severe needle phobia True needle phobia (trypanophobia) is a recognized medical condition that affects approximately 10% of adults

Keeping the injection site clean and dry for several hours post-injection can help minimize local reactions