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Recent studies have demonstrated that spermidine effectively inhibits the phosphorylation of signal transducer and activator of transcription 1 (STAT1) by upregulating protein tyrosine phosphatase non-receptor 2 (PTPN2), thereby promoting macrophage polarization toward the anti-inflammatory M2 phenotype and suppressing excessive inflammatory responses

Leafy vegetables, nuts, whole grains, and vegetable oils are rich in LA, while walnuts, flaxseeds, chia seeds, and soy nuts are rich in ALA

Medication Check whether medication is included, separate, or not clearly published

Episodes often occur in the early morning hours or upon awakening in the morning