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The GHK-Cu peptide was administered intranasally at a dose of 15 mg/kg three times weekly for three months

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Nasal tissue in animals treated with dihydroergotamine mesylate daily at nasal cavity surface area exposures (in mg/mm2) that were equal to or less than those achieved in humans receiving the maximum recommended daily dose of 0.08 mg/kg/day showed mild mucosal irritation characterized by mucous cell and transitional cell hyperplasia and squamous cell metaplasia

The answer is nuanced and can depend on individual factors such as dosage, consistency, and personal health