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IBS affects millions worldwide and can significantly disrupt daily life, often without clear structural abnormalities in the gut

Full-length thymosin beta-4 (T4) is a 43-amino acid endogenous peptide that functions as the primary G-actin sequestering protein in mammalian cells and maintaining the cellular pool of polymerisation-competent actin monomers and regulating cytoskeletal dynamics through its central LKKTETQ actin-binding motif

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The therapeutic activity of dihydroergotamine in migraine is generally attributed to the agonist effect at 5-HT1D receptors