Identifying a target group for selenium supplementation in high-risk cardiac surgery: a secondary analysis of the SUSTAIN CSX trial
Remember that consistency is key, and the most effective approach combines multiple strategies rather than relying on any single intervention
Likewise, many cuproproteins with redox, or redox-with-transport functions (mono-, di-, tetranuclear cupredoxins nitrite reductase, laccase, Cu, Zn-SOD1, amine oxidase CuAO, galactose oxidase, hemocyanin, tyrosinase, catechol oxidase, COX, N 2 O reductase, menaquinol NO reductase et cetera) [47], copper-transporting ATPases (Cu-ATPases, ATP7A and ATP7B) [124,125,126], divalent metal transporter DMT1 [127], copper transporters and chaperons Ctr1, Ctr2, Atox1 and CCS [128, 129], diverse group of bacterial periplasmic copper binding proteins (CopC) [130] are known
However, in the presence of GSH alone, around half of the proteins in the sample retained the intramolecular disulfide, whereas the other half was reduced to the glutathionylated species