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While the nephroprotective effects of SGLT2i were initially derived from secondary endpoints of CV outcome trials (CVOTs), direct confirmation came from dedicated kidney focused trials: CREDENCE (Perkovic et al NEJM 2019| NephJC Summary), DAPA-CKD (Heerspink et al NEJM 2020| NephJC Summary) and finally EMPAKIDNEY (Herrington et al NEJM 2023| NephJC Summary)

Persistent or recurrent infections may indicate antibiotic resistance, inadequate treatment duration, or underlying urological abnormalities requiring further investigation with imaging studies or urology referral

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The Tirzepatide Oral is $349/mo month-to-month, or from $279/mo on the 6-month plan