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While it is not yet known if this risk translates to humans, the medication is not recommended for anyone with a personal or family history of: Medullary thyroid carcinoma (MTC) Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Pancreatitis and Kidney Function If you have a history of pancreatitis, tirzepatide may not be right for you

Off-label prescribing is legal when a licensed healthcare provider determines that a medication may be appropriate for a patient, but it can expand use beyond the exact population studied for the drugs original FDA approval

Mantripragada KK, Spurlock G, Kluwe L, Chuzhanova N, Ferner RE, Frayling IM, et al