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In 2024, resmetirom became the first drug licensed for use in the USA and was subsequently approved by the European Medical Agency (EMA) for the same indication in Europe in August 2025

Here are some examples of the side effects reported by manufacturers

Discuss health history, medications, and goals to determine suitability

Official Wegovy materials list tiredness or fatigue among common side effects, and Ohio States GLP-1 nutrition guidance emphasizes how lower appetite can quietly reduce both food and fluid intake