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Psychiatric adverse events were rare, with two reported in the semaglutide alone group, one in the nimacimab alone group and one in the placebo group

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Data from the STEP [52] and SUSTAIN [53, 54] trials consistently demonstrate that the substantial weight loss achieved with semaglutide at doses of 0.5 mg, 1.0 mg, and 2.4 mg is largely independent of these symptoms, with less than 1% of the total weight loss benefit attributable to GI AEs