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More recently in AWARD-10, the addition of dulaglutide to an SGLT2i also resulted in weight loss, reduced HbA1c, and lower systolic blood pressure [94]

While GLP-1 receptor agonists typically have a low risk of hypoglycemia when used alone, fluctuations in glucose levelsparticularly when combined with insulin or sulfonylureasmay trigger headaches in susceptible individuals

Abbreviations DPP-4: Dipeptidyl peptidase-4 EMA: European Medicines Agency EPAC: Exchange protein directly activated by cAMP FDA: Food and Drug Administration FGF21: Fibroblast growth factor 21 GIP: Glucose-dependent insulinotropic polypeptide GLP-1: Glucagon-like peptide-1 PKA: Protein kinase A SGLT-2: Sodiumglucose cotransporter 2 References Moore B, Edie ES, Abram JS (1906) On the treatment of diabetes mellitus by acid extract of duodenal mucous membrane

Understanding your genetic predisposition can guide evidence-based discussions with providers about personalized supplementation or dietary strategies