Its result of 28.3% over 80 weeks is meaningfully higher than standard Wegovy, higher than Wegovy HD, and higher than the current Zepbound
Therefore, depletion of NADPH stores in G6PD-d has the potential to both limit the production of ROS by NOX family enzymes, while simultaneously expediting the accumulation of ROS from non-NADPH-dependent sources, such as the mitochondrial electron transport chain, peroxisomal -oxidation, oxidative protein folding, and other cytoplasmic enzymes (xanthine oxidase, cyclooxygenase, lipoxygenase) 95,96
The prevalence of the 718TC and 718CC genotypes of the GPX4 gene was higher in the EHCS group as compared with the EH group (OR=2.12, 95%CI 1.423.16, P =0.0002, P adj =0.0018)
Safety-wise, a DEXA scan uses only a very small dose of radiation