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Membrane potential and surface potential in mitochondria: Uptake and binding of lipophilic cations

Very powerful but also nearly impossible to directly impact with medication without blowing out some other system

10.1212/WNL.0000000000000278 214

In diet-induced obese (DIO) mouse models, 5-Amino-1MQ treatment produced significant reductions in body weight, white adipose tissue mass, and adipocyte cell size without significant effects on food intake suggesting a metabolic rather than appetite-suppressing mechanism