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Tirzepatide, a dual glucose-dependent insulinotropic polypeptide/glucagon-like peptide 1 receptor agonist, exhibits favourable effects on pancreatic -cells and hepatic steatosis in obese type 2 diabetic db/db mice

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It is worth emphasizing that the hypoxia microenvironment induced by the E-P-OS network itself can directly activate the transcription of glycolysis-related genes such as glucose transporter 1 and lactate dehydrogenase A via HIF-1, thereby further enhancing glycolysis and ensuring energy supply for fibroid cells under hypoxic conditions [108]

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