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Over time, researchers noticed additional benefits that went well beyond glucose management, including reductions in inflammatory markers and improvements in heart health indicators

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Here, we focus on identifying the effect of more nuanced changes in cholesterol content on exendin-4-mediated GLP-1R function in primary islets and in vivo , followed by mapping of cholesterol binding sites for both apo-state and active receptor structures using coarse-grained molecular dynamics (cgMD) simulations tailored to identify lipid-receptor interactions, and functional validation of a prominent site for its effects on cholesterol binding, plasma membrane behaviours and exendin-4-mediated GLP-1R function in beta cells and primary islets

Study variability Many of the studies assessed were of relatively low quality (case studies or small study groups) and were therefore underpowered, and potentially had selection biases due to unmeasured confounders