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Katayama et al., 2000)

Of the included papers, 16 were randomised control trials (RCT), five were single arm interventional studies, one was a non-randomised comparative interventional study and one was a phase IV clinical trial

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It allows better under-standing of the early steps in the pathophysiology of developing diabetic MVCs and so giving a future hope for novel therapeutic agents preventing the early crawling diabetic vascular disease