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To address this limitation, hydrogels incorporated with metal-based nanozymes exhibiting CAT-like activity, such as copper selenide NPs or MOFs, can sustainably decompose endogenous H 2 O 2 abundantly present in the TME to generate oxygen in situ , thereby effectively alleviating tumor hypoxia

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Oral B12 supplements are absorbed at roughly 1 to 5% in healthy adults, and even less in people with low intrinsic factor, atrophic gastritis, or gut absorption issues