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However, gastrointestinal disorders emerged as the most frequently reported SOC in both datasets, consistent with findings from the STEP 8 Randomized Clinical Trial, where 84.1% of participants reported gastrointestinal adverse events with semaglutide

Additionally, both agents are costly compared to oral therapies, and insurance coverage for their combination is more restrictive than for MDI or premixed insulin, leading to potential financial burden

Statistical analysis The meta-analysis of comparable data was performed using Review Manager 5.0.2 (the Nordic Cochrane Centre, the Cochrane Collaboration, 2008)

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