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doi: 10.3322/caac.21409 22 DamskyWERosenbaumLEBosenbergM

53.4A) (see above) results in depletion of NADPH, which is the cofactor essential for maintaining glutathione in the reduced state

Furthermore, berberine demonstrates antifibrotic effects through several mechanisms, one of which is the induction of G1 phase arrest in hepatic stellate cells (HSCs), preventing their activationan essential process in liver fibrosis