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Studies have found that these subcohorts demonstrate metabolic risk rates substantially higher than in the general public, and have attributed this observational disparity to multiple factors, including patients reduced physical activity, diminished baseline motivation, and the metabolic side effects of essential antipsychotic treatments like olanzapine and clozapine

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There are 3 further SURPASS trials yet to report

A massive July 2025 survey published in the Proceedings of the National Academy of Sciences (PNAS) analyzed treatment efficacy for thousands of patients with Long COVID and ME/CFS